[Endogenous colony formation in closed craniocerebral trauma in mice]

The model of closed brain trauma in mice using stem hematopoietic cell cloning methods has shown inhibited endogenous spleen colony formation and reduced number of reticulocytes in blood circulation during early periods subsequent to traumatic procedure. Maximal inhibition of bone marrow function occurs 4 days after trauma and is accompanied by a dramatic reduction of thymus weight and cellularity. The observed changes in bone marrow function can be one of the important factors leading to lower resistance of the organism to infections during early periods after brain trauma.