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Related Concept Videos

Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Replicative Cell Senescence02:15

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Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Related Experiment Video

Updated: Apr 12, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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Correction: Why Is Aging Conserved and What Can We Do about it?

Jason N Pitt, Matt Kaeberlein

    Plos Biology
    |May 16, 2015
    PubMed
    Summary

    This study corrects a previous article's DOI, ensuring accurate citation and retrieval of scientific findings for researchers globally. Proper citation is crucial for scientific integrity and reproducibility.

    Area of Science:

    • Bibliometrics
    • Scientific Publishing
    • Scholarly Communication

    Context:

    • Accurate citation is fundamental to scientific integrity.
    • Digital Object Identifiers (DOIs) are essential for locating research articles.
    • Ensuring the correct DOI prevents misattribution and aids in tracking research impact.

    Purpose:

    • To correct an erroneous Digital Object Identifier (DOI) associated with a previously published article.
    • To provide the accurate DOI for the article published in PLOS Biology.
    • To facilitate correct referencing and access to the scientific work.

    Summary:

    • The article provides a correction to the Digital Object Identifier (DOI) for a specific publication.
    • The correct DOI is now available for researchers to use for citation and access.

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  • This ensures the article can be accurately found and cited within the scientific community.

    • Impact:

    • Improves the accuracy of scientific literature databases.
    • Enhances the reproducibility of research by ensuring correct source identification.
    • Supports the integrity of scholarly communication and the citation network.