Related Experiment Video
Updated: Apr 12, 2026

Development of Metarhizium anisopliae as a Mycoinsecticide: From Isolation to Field Performance
Published on: July 30, 2017
New pimarane diterpenes and other antimycobacterial metabolites from Anisochilus verticillatus
Roshan R Kulkarni1, Ketaki Shurpali2, Vijay M Khedkar2
1a Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411008 , India.
Abstract:
Phytochemical investigation of the acetone extract of the aerial parts of Anisochilus verticillatus afforded a new 8,9-secopimarane diterpene (1), two new isopimarane diterpenes (2, 3) and the known ursolic acid (4), α-amyrin (5), β-amyrin (6), stigmast-5-en-3-one (7) and hydroxychavicol (8). Structures of the new compounds were elucidated with the help of 1D and 2D nuclear magnetic resonance spectroscopic data, and single crystal X-ray crystallography of compound 3. Compounds 2 and 8 inhibited Mycobacterium tuberculosis H37Ra with an IC50 of 11.3 (IC90 of 20.0 μg/mL) and 12.5 μg/mL, respectively. Correspondingly, molecular docking studies with Extra Precision Glide revealed a correlation between score and biological activity for these compounds to describe the molecular basis for the most significant SAR results.
Related Concept Videos
Anthelminthic Agents
Antifungal Agents
iChip
Bacterial Phylum Actinobacteria
Bacterial Phylum Planctomycetes
Bacterial Phylum Tenericutes

