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[The possibility of using PlasmaDeepDive™ MRM panel in clinical diagnostics]
Iu V Miroshnichenko1, N A Petushkova1, N E Moskaleva1
1Institute of Biomedical Chemistry, Moscow, Russia.
Biomeditsinskaia Khimiia
|May 16, 2015
Summary
The PlasmaDeepDive™ MRM Panel accurately measured 46 human plasma proteins, with 18 confirmed by shotgun proteomics. This panel is suitable for identifying potential nervous system disorder biomarkers.
Area of Science:
- Proteomics
- Biochemistry
- Neuroscience
Context:
- Human plasma protein quantification is crucial for biomarker discovery.
- Shotgun proteomic analysis provides a broad overview of the proteome.
- Nervous system disorders require sensitive and specific diagnostic tools.
Purpose:
- To evaluate the PlasmaDeepDive™ MRM Panel for human plasma protein analysis.
- To determine the panel's suitability for biomarker studies in neurological diseases.
Summary:
- Quantified 46 proteins in human plasma using the PlasmaDeepDive™ MRM Panel.
- 18 proteins identified by the panel were also detected via shotgun proteomics.
- Literature review supports the panel's utility for nervous system disorder biomarker research.
Impact:
- The PlasmaDeepDive™ MRM Panel demonstrates applicability for human plasma biomarker studies.
- Potential for advancing the diagnosis and understanding of nervous system disorders.
- Provides a validated tool for future proteomic research in neurology.
