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Related Experiment Video

Updated: Apr 12, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
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Pulmonary function in infants with swallowing dysfunction.

James D Tutor1, Saumini Srinivasan1, Memorie M Gosa2

  • 1Program in Pediatric Pulmonary Medicine, University of Tennessee Health Science Center, Le Bonheur Children's Hospital and St. Jude Children's Research Hospital, Memphis, TN, United States of America.

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|May 16, 2015
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Summary

Infant swallowing dysfunction often causes lung issues like cough and wheezing. Six months of therapy did not significantly improve pulmonary function, suggesting long-term studies are needed for these infants.

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Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology
  • Neonatology

Background:

  • Swallowing dysfunction in infants is linked to aspiration and chronic respiratory symptoms like cough and wheezing.
  • This study investigates pulmonary function in infants with swallowing dysfunction and the impact of therapy.

Purpose of the Study:

  • To characterize pulmonary function abnormalities in infants with swallowing dysfunction.
  • To assess the effectiveness of medical therapy in improving these abnormalities.

Main Methods:

  • Pulmonary function tests (spirometry, plethysmography) were performed on 38 infants with swallowing dysfunction.
  • Tests were repeated after 6 months of medical therapy for swallowing dysfunction/gastroesophageal reflux in 17 infants.
  • Co-morbidities like gastroesophageal reflux and passive smoke exposure were noted.

Main Results:

  • Initially, a majority of infants showed abnormal spirometry (25/38), abnormal plethysmography (18/38), and 15/38 demonstrated bronchodilator responsiveness.
  • After 6 months, pulmonary function improvements were inconsistent, with many infants still showing abnormalities or changes in responsiveness.
  • Co-existing conditions like GERD and smoke exposure complicated interpretation of results.

Conclusions:

  • Medical therapy for swallowing dysfunction and GERD did not significantly improve pulmonary function in infants after 6 months.
  • The high prevalence of co-morbidities complicates the assessment of lung function changes.
  • Further long-term studies are required to understand the persistent effects on adult lung function.