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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
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Leukemoid reaction to Clostridium difficile infection.

Ashutossh Naaraayan1, Melissa Aleta1, Prasanta Basak1

  • 1Department of Internal Medicine, Montefiore New Rochelle Hospital, Albert Einstein College of Medicine, 16 Guion Place, New Rochelle, NY, 10801, USA.

Anaerobe
|May 17, 2015
PubMed
Summary

Clostridium difficile infection (CDI) can cause a severe leukemoid reaction, a rare sign indicating a poor prognosis. This case highlights the challenges in managing severe CDI, even with prompt treatment.

Keywords:
Clostridium difficileLeukemoid reactionToxic megacolon

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Area of Science:

  • Infectious Diseases
  • Hematology

Background:

  • Clostridium difficile infection (CDI) incidence and severity are rising globally.
  • Leukemoid reaction is an uncommon finding in CDI cases.

Observation:

  • An elderly female patient presented with Clostridium difficile infection.
  • The patient exhibited a marked leukemoid reaction.

Findings:

  • Leukemoid reaction in CDI is associated with severe disease and a grave prognosis.
  • Despite early antibiotic treatment and surgical consultation, the patient succumbed to the infection.

Implications:

  • This case underscores the critical nature of CDI with leukemoid reaction.
  • Highlights the need for vigilance and potentially novel therapeutic strategies for severe CDI cases.