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Related Experiment Videos

Mania in the elderly.

K Stone1

  • 1Department of Psychiatry, Central Manchester Health Authority, Manchester Royal Infirmary.

The British Journal of Psychiatry : the Journal of Mental Science
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Late-onset mania in older adults often presents without prior mood episodes. While prognosis is generally good, lithium prophylaxis shows limited impact on readmissions and carries a risk of toxicity.

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Area of Science:

  • Geriatric Psychiatry
  • Mood Disorders
  • Neuropsychiatry

Background:

  • Late-onset mania in individuals over 65 is a distinct clinical presentation.
  • Understanding the characteristics and outcomes of this patient group is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical features, illness history, and treatment outcomes of elderly patients (over 65) admitted with mania.
  • To explore the role of family history and cerebral organic impairment on age of onset.

Main Methods:

  • Retrospective study of 92 patients aged over 65 admitted with mania.
  • Analysis of prior affective illness history, family history, and presence of cerebral organic impairment.
  • Evaluation of treatment with lithium prophylaxis and patient outcomes at six months.

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Main Results:

  • 26% of patients had no prior affective illness history; 30% had only experienced depression previously.
  • Family history of affective disorders correlated with earlier onset; cerebral organic impairment with later onset.
  • Prognosis was favorable, with 8% remaining hospitalized at six months. Lithium prophylaxis did not significantly reduce readmissions, and 25% developed toxicity.

Conclusions:

  • Late-onset mania in the elderly can occur de novo or following depression, with varying onset predictors.
  • Lithium's efficacy in preventing readmissions is questionable in this population, and toxicity is a concern.