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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Association between apolipoprotein E gene polymorphism and depression.

Fang Feng1, Shan-Shan Lu1, Cai-Yun Hu1

  • 1Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|May 17, 2015
PubMed
Summary
This summary is machine-generated.

The apolipoprotein E (ApoE) ε2/ε3 genotype may protect against depression overall, while the ε2 allele is protective in Caucasians. The ε4 allele and ε3/ε4 genotype increase late-life depression risk.

Keywords:
ApoEApolipoprotein EDepressionMeta-analysisPolymorphism

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Area of Science:

  • Genetics and Psychiatry
  • Molecular Biology
  • Epidemiology

Background:

  • Inconsistent findings exist regarding the association between apolipoprotein E (ApoE) gene polymorphism and depression.
  • A precise estimation of this relationship is needed to clarify genetic risk factors for depression.

Purpose of the Study:

  • To conduct an updated meta-analysis to determine the association between ApoE gene polymorphism and depression susceptibility.
  • To provide a more accurate assessment of the genetic link between ApoE and depression.

Main Methods:

  • Meta-analysis of twenty studies including 2286 depression patients and 3845 controls.
  • Calculation of odds ratios (OR) with 95% confidence intervals (CI) using a random effects model.
  • Subgroup analyses were performed for population and depression type.

Main Results:

  • A significant association was found between ApoE gene polymorphism and depression in the overall population (ε2/ε3 genotype vs. ε3/ε3: OR 0.76).
  • In Caucasians, the ε2 allele showed a protective effect (vs. ε3: OR 0.75).
  • In late-life depression (LLD), the ε3/ε4 genotype (vs. ε3/ε3: OR 1.34) and ε4 allele (vs. ε3: OR 1.30) were associated with increased risk.

Conclusions:

  • The ApoE ε2/ε3 genotype appears protective against depression in the general population.
  • The ApoE ε2 allele is a protective factor for depression in Caucasians.
  • The ApoE ε4 allele and ε3/ε4 genotype are linked to an elevated risk of late-life depression.