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Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Myasthenia Gravis: Diagnostic Tests01:15

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Related Experiment Video

Updated: Apr 12, 2026

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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Guillain-Barré syndrome.

Vibhuti Ansar1, Nojan Valadi2

  • 1Department of Medical Education, Midtown Medical Center, Columbus Regional Healthcare, 1900 10th Avenue, Suite 100, Columbus, GA 31901, USA.

Primary Care
|May 17, 2015
PubMed
Summary

Guillain-Barré syndrome is a neurological disorder causing progressive weakness and paralysis, potentially leading to respiratory failure. Early diagnosis and treatments like plasma exchange can improve outcomes and prevent lasting debility.

Keywords:
Acute inflammatory demyelinating polyradiculoneuropathy (AIDP)Acute motor axonal neuropathyDemyelinating syndromeGuillain-Barré syndromeMiller Fisher syndrome

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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
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Area of Science:

  • Neurology
  • Clinical Immunology

Background:

  • Guillain-Barré syndrome (GBS) encompasses rapidly progressive, potentially fatal neurological disorders.
  • Unrecognized or untreated GBS can lead to significant morbidity and mortality.
  • Ascending limb weakness and paralysis are hallmark symptoms, potentially progressing to respiratory compromise.

Purpose of the Study:

  • To review the clinical presentation, diagnosis, and management of Guillain-Barré syndrome.
  • To highlight the importance of timely recognition and intervention in GBS cases.
  • To discuss treatment modalities and prognosis associated with GBS variants.

Main Methods:

  • Clinical diagnosis based on characteristic symptoms.
  • Supportive laboratory testing.
  • Review of established treatment protocols including plasma exchange and intravenous immunoglobulin.

Main Results:

  • Most Guillain-Barré syndrome cases resolve without long-term neurological deficits.
  • Prompt treatment can mitigate severity and reduce mortality.
  • A subset of patients may experience persistent debility despite treatment.

Conclusions:

  • Guillain-Barré syndrome requires prompt clinical recognition and management.
  • Effective treatments are available, improving patient outcomes.
  • Awareness of GBS variants and potential for residual deficits is crucial for patient care.