Related Experiment Video
Updated: Apr 12, 2026
Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective
Published on: January 12, 2024
Aggressive Therapy Reduces Disease Activity without Skeletal Damage Progression in Chronic Nonbacterial Osteomyelitis
Yongdong Zhao1, Nancy A Chauvin1, Diego Jaramillo1
1From the Pediatric Rheumatology Department, Seattle Children's Hospital, Seattle, Washington; Department of Radiology, and the Division of Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.Y. Zhao, MD, PhD, acting assistant professor, Pediatric Rheumatology Department, Seattle Children's Hospital; N.A. Chauvin, MD, Assistant Professor; D. Jaramillo, MD, MPH, Professor, Department of Radiology, The Children's Hospital of Philadelphia; J.M. Burnham, MD, MSCE, Associate Professor, Division of Pediatric Rheumatology, The Children's Hospital of Philadelphia.
Objective:
To retrospectively assess changes in disease activity and skeletal damage in children with chronic nonbacterial osteomyelitis (CNO) after infliximab and methotrexate, with or without zoledronic acid or nonsteroidal antiinflammatory drug (NSAID) monotherapy, using a standardized magnetic resonance imaging (MRI) approach.
Methods:
Treatment-related changes in clinical and MRI measures from aggressive therapy and NSAID monotherapy groups (n = 9 per group) were evaluated using nonparametric methods.
Results:
Pain, physical function, physician global assessment, inflammatory markers, nonvertebral inflammatory lesion number, and maximum bone edema score all improved significantly with aggressive therapy (p < 0.03), whereas only the maximum soft tissue inflammation severity decreased (p = 0.02) with NSAID monotherapy. Vertebral deformities and physeal damage did not worsen in the aggressive therapy group but 1 in the NSAID group had worsening of growth plate damage.
Conclusion:
An aggressive treatment regimen in CNO improved clinical and imaging measures of disease activity without progression of skeletal damage.
