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CCR 20th Anniversary Commentary: Expanding the Epigenetic Therapeutic Portfolio

Susan E Bates1, Robert W Robey2, Richard L Piekarz3

  • 1Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. batess@helix.nih.gov.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|May 17, 2015
PubMed

Insights

Histone deacetylase (HDAC) inhibitors show promise as anticancer drugs. A phase I trial found romidepsin, a potent HDAC inhibitor, to be tolerable and effective in T-cell lymphoma, driving further epigenetic agent research.

Area of Science:

  • Epigenetics and Drug Discovery
  • Oncology
  • Pharmacology

Background:

  • Epigenetic modifications are crucial in cancer development.
  • Histone deacetylase (HDAC) inhibitors have demonstrated significant anticancer potential.
  • Early research indicated HDAC inhibitors' efficacy in T-cell lymphoma.

Purpose of the Study:

  • To evaluate the safety and tolerability of romidepsin, a novel HDAC inhibitor.
  • To assess the preliminary efficacy of romidepsin in a phase I clinical trial.
  • To establish the characteristic side effect profile for HDAC inhibitors.

Main Methods:

  • Phase I clinical trial design.
  • Administration of romidepsin (depsipeptide).
  • Monitoring of patient tolerability and side effects.

Main Results:

  • Romidepsin was found to be tolerable in patients.
  • A side effect profile characteristic of HDAC inhibitors was observed.
  • Evidence of clinical activity was noted, supporting further investigation.

Conclusions:

  • Romidepsin is a tolerable HDAC inhibitor with potential anticancer activity.
  • The phase I trial provided crucial data for the development of epigenetic therapies.
  • This study propelled further research into epigenetic agents for cancer treatment.

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