Related Experiment Video

Updated: Apr 12, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

25.2K

Squamous cell lung cancer: from tumor genomics to cancer therapeutics

David R Gandara1, Peter S Hammerman2, Martin L Sos3

  • 1Davis Comprehensive Cancer Center, University of California, Sacramento, California. david.gandara@ucdmc.ucdavis.edu.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|May 17, 2015
PubMed

Insights

Advances in understanding squamous cell lung cancer (SCC) biology are yielding new molecular targets and therapeutic agents. Innovative clinical trials offer hope for patients with advanced SCC.

Area of Science:

  • Oncology
  • Pulmonary Medicine
  • Molecular Biology

Background:

  • Squamous cell lung cancer (SCC) therapy has lagged behind adenocarcinoma, representing a significant unmet need.
  • Recent research is uncovering the complex biology of SCC, identifying novel genomic and signaling pathways.
  • This progress is leading to the discovery of new molecular targets and therapeutic strategies.

Purpose of the Study:

  • To review the current therapeutic landscape for SCC.
  • To highlight recent advances in understanding SCC biology and identifying prognostic gene signatures.
  • To discuss innovative clinical trials and their potential impact on SCC treatment.

Main Methods:

  • Comprehensive literature review of SCC biology, therapeutics, and clinical trials.
  • Analysis of emerging prognostic gene signatures and predictive biomarkers.
  • Examination of ongoing clinical trial designs, including master protocols like Lung-MAP.

Main Results:

  • Characterization of novel SCC-associated molecular abnormalities and signaling pathways.
  • Development of targeted agents against unique SCC molecular targets.
  • Emergence of SCC-specific prognostic gene signatures and predictive biomarkers.

Conclusions:

  • Recent biological insights and targeted therapies offer new hope for advanced SCC patients.
  • Innovative clinical trial designs are facilitating the approval of targeted therapy-biomarker combinations.
  • Continued research into SCC biology is crucial for advancing treatment options.

More Related Videos

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.9K
Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

543

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
56.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

3.1K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.6K