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Related Concept Videos

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis05:44

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Experimental autoimmune encephalomyelitis is one of the most widely used murine models of multiple sclerosis. In the current protocol, C57BL/6J mice of both sexes are immunized with myelin oligodendrocyte glycoprotein peptide, resulting mainly in ascending paresis of the tail and limbs. Here we discuss the protocol of EAE induction and evaluation.
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The goal of this pilot study is to describe a protocol for the remotely-supervised delivery of transcranial direct current stimulation (tDCS) so that the procedure maintains standards of in-clinic practice, including safety, reproducibility, and tolerability. The feasibility of this protocol was tested in participants with multiple sclerosis (MS).
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Precise measurement of neurological and neuropsychological impairment and disability in multiple sclerosis is challenging. We report methodologic details on a new test, the Multiple Sclerosis Performance Test (MSPT). This new approach to the objective of quantification of MS related disability provides a computer-based platform for precise, valid measurement of MS...
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Related Experiment Video

Updated: Jan 20, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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How can proteomics elucidate the complexity of multiple sclerosis?

Alessandro S Farias1, Leonilda M B Santos1

  • 1Neuroimmunomodulation Group and Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas, Campinas, São Paulo, Brazil.

Proteomics. Clinical Applications
|May 19, 2015
PubMed
Summary

Proteomics offers new insights into multiple sclerosis (MS) pathogenesis by identifying disease biomarkers and therapeutic targets. Further analysis of proteomics data from MS models and patients is crucial for understanding neurodegeneration.

Keywords:
Experimental autoimmune encephalomyelitisInflammationMultiple sclerosisNeurodegenerationProteomics

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Area of Science:

  • Neuroscience
  • Immunology
  • Biochemistry

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) affecting over 2.5 million people globally.
  • Despite extensive research for 150 years, significant knowledge gaps persist regarding MS etiology, diagnosis, prognosis, and pathogenesis, particularly concerning neurodegenerative mechanisms.
  • Current MS therapies predominantly target the inflammatory aspects, highlighting a need for deeper understanding of underlying disease processes.

Purpose of the Study:

  • To explore the utility of proteomics in unraveling molecular pathways and identifying differentially expressed proteins in multiple sclerosis.
  • To leverage proteomics for the discovery of novel biomarkers, potential therapeutic targets, and regulatory mechanisms in MS.
  • To assess the existing body of proteomics research in MS, encompassing both experimental models and human patient samples.

Main Methods:

  • Review and analysis of existing proteomics studies conducted on samples from multiple sclerosis experimental models.
  • Examination of proteomics data derived from patients diagnosed with multiple sclerosis.
  • Identification and quantification of differentially expressed proteins using proteomic techniques.

Main Results:

  • Proteomics has emerged as a powerful tool for revealing molecular pathways implicated in MS.
  • Proteomic studies have identified numerous differentially expressed proteins, laying a foundation for biomarker discovery.
  • A substantial volume of proteomics data from MS models and patients is available for further investigation.

Conclusions:

  • Proteomics holds significant promise for advancing the understanding of MS pathogenesis, particularly neurodegenerative mechanisms.
  • The accumulated proteomics data provides a solid basis for future validation and the development of targeted therapies.
  • Further analysis of proteomics data is essential for discovering novel biomarkers and therapeutic strategies for multiple sclerosis.