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Increased serum resistin levels correlate with psoriasis: a meta-analysis
Huiyun Huang1, Erdong Shen2, Shiqing Tang3
1Dermatological Department, the First People's Hospital of YueYang, Dong Mao Ling Road No.39, YueYang, 414000, P.R. China. huanghuiyun0416@163.com.
Lipids in Health and Disease
|May 19, 2015
Summary
Serum resistin levels are significantly elevated in psoriasis patients compared to healthy individuals. This finding suggests resistin may serve as a novel diagnostic marker for psoriasis.
Area of Science:
- Biochemistry
- Immunology
- Dermatology
Background:
- Adipokines are implicated in inflammatory disease pathogenesis.
- Psoriasis is an inflammatory skin condition.
- Resistin is an adipokine of interest.
Purpose of the Study:
- To evaluate the significance of serum resistin levels in psoriasis patients.
- To conduct a meta-analysis on resistin and psoriasis.
Main Methods:
- Systematic search of multiple English and Chinese databases.
- Inclusion of nine case-control studies.
- Statistical analysis using STATA software.
Main Results:
- A significant association was found between elevated serum resistin levels and psoriasis (SMD=2.22, P<0.001).
- Higher resistin levels were observed in both Asian and Caucasian psoriasis patients compared to controls.
- Subgroup analysis confirmed increased resistin in both ethnic groups.
Conclusions:
- Serum resistin levels are higher in psoriasis patients.
- Elevated resistin may be a novel diagnostic marker for psoriasis.
- Resistin may predict psoriasis comorbidities.
