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Updated: Apr 12, 2026

Translational Rabbit Model of Chronic Cardiac Pacing
Published on: January 6, 2023
Complications and Risk Assessment of 25 Years in Pediatric Pacing
B Jakub Wilhelm1, Marc Thöne2, Tarik El-Scheich3
1Easton Hospital, Department of Surgery, Drexel University College of Medicine, Easton, Pennsylvania; Division of Cardiovascular Surgery, Heinrich Heine University Hospital Düsseldorf, Düsseldorf, Germany.
Insights
Pediatric cardiac pacing presents challenges, with endocardial leads showing higher rates of lead problems and venous thrombosis, especially in younger children. An individualized approach is crucial for both endocardial and epicardial systems.
Area of Science:
- Pediatric Cardiology
- Biomedical Engineering
- Cardiac Electrophysiology
Background:
- Pediatric pacemaker implantation is a specialized field with unique surgical challenges due to small patient anatomy.
- Children undergoing pacemaker procedures face specific complications distinct from adult populations.
- This study investigates complications and risk factors associated with endocardial and epicardial pacemaker systems in pediatric patients.
Purpose of the Study:
- To analyze complications in pediatric patients with endocardial and epicardial pacemaker systems.
- To identify specific risk factors associated with pacemaker implantation in children.
- To compare the outcomes of endocardial versus epicardial pacing in pediatric populations.
Main Methods:
- Retrospective evaluation of pacemaker-related operations in pediatric patients (<18 years) from 1985-2010.
- Collection of demographic data including age, height, and weight.
- Separate analysis of idiopathic and postoperative dysrhythmias.
Main Results:
- 149 operations in 73 pediatric patients were analyzed.
- Epicardial leads had higher pacing thresholds (17.2%) compared to endocardial leads (2.9%).
- Endocardial leads experienced more lead problems (30.4%) and venous thrombosis (13.7%), particularly in patients <15 kg.
Conclusions:
- Pediatric cardiac pacing is complex, often requiring multiple reoperations throughout a patient's life.
- Neither epicardial nor endocardial pacing systems demonstrate clear superiority.
- An individualized treatment strategy is essential for pediatric pacemaker patients.
Background:
Children who require cardiac pacemaker implantation have presented a small patient sub-population since the breakthrough of this technology in the 1950s and 1960s. Their small bodies result in a technical challenge for the operating surgeon and put the patient at risk for a series of specific complications. Our study aims to analyze complications and to identify risk factors of endocardial and epicardial pacemaker systems in children.
Methods:
All pacemaker-related operations in pediatric patients up to the age of 18 years from 1985 through 2010 were retrospectively evaluated. Demographic data including age, height, and weight were recorded. Idiopathic and postoperative dysrhythmias were analyzed separately.
Results:
A total of 149 pacemaker operations were performed in 73 patients. Thirty-two patients did not have a previous cardiac operation. Indications for revision included box exchange, lead-related problems, pacemaker pocket complications, impaired left ventricular function, and pectoral muscle stimulation. Increased pacing thresholds occurred in 17.2% of the patients with epicardial leads compared with 2.9% in the endocardial group. Aside from threshold-related revision, lead problems are more common in the endocardial group (30.4% vs 17.2%). Venous thrombosis occurred in 13.7% of the patients (only endocardial), preferentially (25%) in the weight group less than 15 kg and in idiopathic patients (15.6% vs 10.5% with prior cardiac surgery).
Conclusions:
Cardiac pacing is particularly challenging in the pediatric patient population facing a large number of reoperations during their lifetime. The lack of clear superiority of either epicardial or endocardial pacing systems requires an individual concept.
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