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Related Experiment Video

Updated: Apr 12, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Corneal cross-linking.

J Bradley Randleman¹, Sumitra S Khandelwal², Farhad Hafezi³

¹Department of Ophthalmology, Emory University, Atlanta, Georgia, USA; Emory Vision, Emory Eye Center, Atlanta, Georgia, USA.

Survey of Ophthalmology

|May 19, 2015

Summary

This summary is machine-generated.

Corneal cross-linking, using riboflavin and UV-A light, stiffens the cornea to treat progressive thinning diseases like keratoconus. This established technique continues to evolve, with ongoing research into its fundamental mechanisms and broader applications.

Keywords:

CXL accelerated cross-linking cornea cross-linking cross-linking plus ectasia infectious keratitis keratoconus

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Area of Science:

Ophthalmology
Biomaterials Science
Tissue Engineering

Background:

Corneal ectatic diseases, such as keratoconus, are characterized by progressive corneal thinning and weakening.
Corneal cross-linking (CXL) has emerged as a standard treatment to halt disease progression.
The fundamental principles of CXL are still being elucidated, particularly regarding oxygen's role and optimal treatment parameters.

Purpose of the Study:

To provide a comprehensive overview of corneal cross-linking (CXL).
To discuss the scientific basis and evolution of CXL techniques.
To explore current and future applications of CXL in ophthalmology.

Main Methods:

Review of historical development and scientific literature on corneal cross-linking.
Analysis of current clinical protocols and treatment parameters.
Discussion of CXL's application in conjunction with other ophthalmic procedures.

Main Results:

Corneal cross-linking effectively stiffens the cornea, arresting progression of ectatic disorders.
The versatility of CXL stems from its basis as a physiological principle for connective tissue strengthening.
Ongoing research aims to optimize CXL parameters and expand its therapeutic scope.

Conclusions:

Corneal cross-linking is a vital treatment for corneal ectatic diseases, with a solid scientific foundation.
Further research into CXL mechanisms will refine clinical applications.
CXL holds promise for treating infectious keratitis and enhancing refractive surgery outcomes.