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Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold

Bernard Barlaam1, Sabina Cosulich1, Martina Fitzek1

  • 1AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.

Bioorganic & Medicinal Chemistry Letters
|May 19, 2015
PubMed

Keywords:
Kinase selectivityPI3Kα inhibitor

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