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Related Experiment Video

Updated: Apr 12, 2026

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
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The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of

Marie-Aline Neveu1, Vanesa Bol2, Anne Bol2

  • 1Biomedical Magnetic Resonance Research Group, Université catholique de Louvain (UCL), Belgium.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|May 19, 2015
PubMed
Summary

Carbogen breathing significantly reduced 18F-FDG uptake in tumors, indicating rapid metabolic adaptation to increased oxygen levels. This finding impacts understanding tumor metabolism and response to therapy.

Keywords:
(18)F-FDG-PETCarbogenEPRTumor oxygenation

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Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
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Area of Science:

  • Oncology
  • Medical Imaging
  • Cancer Research

Background:

  • Tumor oxygenation is a critical factor influencing treatment response.
  • Understanding metabolic adaptations in tumors is key to developing effective therapies.

Purpose of the Study:

  • To investigate the effect of carbogen breathing on 18F-FDG uptake in different tumor models.
  • To correlate oxygenation status with metabolic changes during hyperoxic conditions.

Main Methods:

  • Utilized Electron Paramagnetic Resonance (EPR) oximetry to measure tumor oxygenation.
  • Employed Positron Emission Tomography (PET) with 18F-FDG to assess glucose metabolism.
  • Administered carbogen breathing challenge to alter tumor oxygenation.

Main Results:

  • A significant decrease in 18F-FDG uptake was observed under carbogen breathing.
  • EPR oximetry confirmed changes in tumor oxygenation status.
  • The results suggest a rapid metabolic adaptation to the hyperoxic environment.

Conclusions:

  • Carbogen breathing induces a rapid metabolic adaptation in tumors, decreasing 18F-FDG uptake.
  • Tumor metabolic response to oxygenation changes warrants further investigation for therapeutic strategies.
  • This study provides insights into the dynamic interplay between tumor oxygenation and metabolism.