The association of J wave and ventricular tachycardia before device implantation with device interventions for
Hideki Hayashi1, Minoru Horie1
1Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.
Insights
J waves and a history of ventricular tachycardia (VT) predict future defibrillator interventions in patients with implanted devices. These findings aid in assessing arrhythmia risk and guiding treatment strategies.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- J waves are linked to life-threatening ventricular arrhythmias in various heart conditions.
- A prior diagnosis of ventricular tachycardia (VT) is a known risk factor for future arrhythmic events.
Purpose of the Study:
- To identify prognostic factors for ventricular tachyarrhythmias in patients with implanted defibrillators.
Main Methods:
- Analysis of intracardiac electrograms in patients with implantable cardioverter-defibrillators (ICDs) or cardiac resynchronization therapy with a defibrillator (CRT-D).
- Retrospective evaluation using multivariate Cox proportional hazards models to assess the relationship between clinical characteristics and device interventions for ventricular tachyarrhythmias.
Main Results:
- The study included 160 patients with a mean follow-up of 44 months.
- J waves were present in 19% and documented VT in 48% of patients prior to device implantation.
- J waves (HR, 2.90) and prior VT (HR, 4.34) were independent predictors of device intervention, even after adjusting for confounders.
Conclusions:
- J waves and a documented history of VT are independent predictors of future device interventions for ventricular tachyarrhythmias.
- These factors are crucial for risk stratification in patients with implanted defibrillators.
Background:
J wave is known to be associated with increased risk of life-threatening ventricular arrhythmias in both structural and nonstructural heart disease. A documented history of ventricular tachycardia (VT) is also a known predictor for future arrhythmic events. The purpose of this study is to investigate prognostic factors in ventricular tachyarrhythmias in patients with an implanted defibrillator.
Methods:
Intracardiac electrograms were thoroughly analyzed in patients with either an implanted implantable cardioverter-defibrillator or with cardiac resynchronization therapy with a defibrillator. The relation between the clinical characteristics and the device interventions for ventricular tachyarrhythmias was evaluated retrospectively with multivariate Cox proportional hazards models.
Results:
This study enrolled a total of 160 patients who were followed for a mean period of 44 ± 28 months. Of these patients, 31 (19%) showed J wave and 77 (48%) showed documented VT before the device implantation. Multivariate Cox proportional hazards models revealed that the presence of J wave and the documented history of VT before the device implantation were independently associated with device intervention in patients with device implantation even after the adjustment of confounding factors (hazard ratio [HR], 2.90; 95% confidence interval [CI], 1.56-5.24; p=0.001 and HR, 4.34; 95% CI, 2.43-8.05; p<0.0001, respectively).
Conclusion:
The presence of J wave and the documented history of VT prior to device implantation served as independent predictors of future device intervention for ventricular tachyarrhythmias.
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