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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

365
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
365
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

816
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
816
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

333
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
333
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

351
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
351
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

329
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
329
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

343
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
343

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Pseudofracture: An Acute Peripheral Tissue Trauma Model
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Trauma in the geriatric population.

Cathy A Maxwell1

  • 1Vanderbilt University School of Nursing, 461 21st Avenue South - GH 420, Nashville, TN 37240, USA.

Critical Care Nursing Clinics of North America
|May 19, 2015
PubMed
Summary
This summary is machine-generated.

Geriatric trauma is a growing public health concern. This article reviews the epidemiology and optimal care for older adults, focusing on frailty and care transitions.

Keywords:
Advanced care planningEpidemiologyEvidence-based managementFrailtyGeriatric traumaInjured older adultsInjury prevention

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Area of Science:

  • Gerontology
  • Trauma Surgery
  • Public Health

Background:

  • Injury in older adults represents a significant and escalating public health crisis.
  • Geriatric trauma encompasses a complex interplay of physiological changes and comorbidities specific to aging.
  • The aging population necessitates specialized approaches to trauma care to mitigate adverse outcomes.

Purpose of the Study:

  • To provide a comprehensive overview of geriatric trauma.
  • To outline optimal patient care strategies across the continuum of care for older adults with injuries.
  • To highlight key considerations such as frailty assessment and care transitions.

Main Methods:

  • Review of the epidemiology of geriatric trauma.
  • Presentation of optimal approaches for patient triage, transport, and trauma team activation.
  • Discussion of inpatient management strategies and injury prevention measures.

Main Results:

  • Geriatric trauma requires specialized protocols for assessment and management.
  • Early identification of frailty and proactive advanced care planning are crucial.
  • Effective transitions of care are essential for improving outcomes in older trauma patients.

Conclusions:

  • Addressing geriatric trauma requires a multidisciplinary approach.
  • Integrating frailty assessment and advanced care planning improves patient-centered care.
  • Optimizing the continuum of care, from pre-hospital to post-discharge, is vital for geriatric trauma survivors.