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Testosterone and obesity.

D M Kelly1, T H Jones1,2

  • 1Department of Human Metabolism, Medical School, The University of Sheffield, Sheffield, UK.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|May 19, 2015
PubMed
Summary
This summary is machine-generated.

Low testosterone levels contribute to obesity and metabolic dysfunction in men. Testosterone replacement therapy may aid weight management in obese men with hypogonadism.

Keywords:
Adiposeandrogenmetabolismtype 2 diabetes

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Obesity Research

Background:

  • Testosterone plays a crucial role in metabolic health, with low levels linked to increased fat mass, reduced lean mass, and metabolic dysfunction.
  • A bidirectional relationship exists between testosterone and obesity, forming a hypogonadal-obesity cycle where weight loss can improve testosterone levels.

Purpose of the Study:

  • To explore the intricate relationship between testosterone and obesity.
  • To investigate the mechanisms of testosterone action in metabolic regulation.
  • To evaluate the efficacy of testosterone replacement therapy (TRT) as an adjunctive treatment for weight management in obese hypogonadal men.

Main Methods:

  • Review of existing literature on testosterone's role in metabolic diseases.
  • Analysis of androgenic effects on enzymatic pathways related to fatty acid metabolism, glucose control, and energy utilization.
  • Examination of clinical evidence regarding the impact of TRT on obesity parameters and lifestyle factors.

Main Results:

  • Testosterone deficiency is associated with increased adiposity, impaired glucose control, reduced insulin sensitivity, and dyslipidemia.
  • Androgenic effects are tissue-specific, influencing fat depots, muscle, and liver metabolism.
  • TRT shows potential benefits for obesity measures, partly through direct metabolic actions and partly by enhancing motivation and energy levels for increased physical activity.

Conclusions:

  • Testosterone is integral to metabolic health, and its deficiency exacerbates obesity and related dysfunctions.
  • TRT can offer beneficial effects on obesity, with outcomes potentially influenced by treatment duration and modality.
  • Testosterone replacement may serve as a valuable adjunctive therapy for weight management in obese men with hypogonadism.