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Hyperglycemia associated with seizure control in status epilepticus
Piyawan Chiewthanakul1, Parinya Noppaklao2, Kittisak Sawanyawisuth3
1Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand.
Epilepsy & Behavior : E&B
|May 19, 2015
Summary
High plasma glucose and low serum albumin levels are linked to uncontrolled seizures in patients with status epilepticus (SE) outside of neurointensive care units (NICU). These findings highlight key factors for managing SE in non-NICU settings.
Area of Science:
- Neurology
- Critical Care Medicine
Background:
- Status epilepticus (SE) is a critical neurological emergency with significant mortality.
- Limited data exists on seizure control factors in non-neurointensive care units (non-NICU).
Purpose of the Study:
- To identify clinical factors associated with uncontrolled status epilepticus (SE) in adult patients admitted to a non-NICU setting.
Main Methods:
- Retrospective analysis of 211 adult SE patients at Khon Kaen hospital (2010-2012).
- Patients were classified into controlled and uncontrolled seizure groups.
- Multivariate logistic regression analyzed clinical factors correlating with uncontrolled SE.
Main Results:
- 27.01% of patients achieved controlled seizures.
- Elevated plasma glucose (OR 1.008) and low serum albumin (OR 0.166) were significant predictors differentiating controlled from uncontrolled SE.
- Central nervous system infections and cardiac arrest were strongly associated with uncontrolled SE.
Conclusions:
- High plasma glucose and low serum albumin levels are key etiological factors associated with uncontrolled SE in non-NICU settings.
- These biochemical markers can aid in predicting and managing SE outside specialized intensive care environments.
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