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Holotranscobalamin Levels in Children with Helicobacter pylori Infection

Oguz Afyoncu1, Orhan Gursel2, Avni Atay2

  • 1Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.

Helicobacter
|May 19, 2015
PubMed

Insights

Helicobacter pylori infection in children lowers vitamin B12 status, specifically holotranscobalamin (holoTC) levels. This effect is reversible and normalizes after H. pylori treatment.

Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Biochemistry

Background:

  • Helicobacter pylori (H. pylori) infection is common in children.
  • Vitamin B12 deficiency can lead to various health issues.
  • Holotranscobalamin (holoTC) is an active form of vitamin B12.

Purpose of the Study:

  • To investigate the association between H. pylori infection and vitamin B12 levels in children.
  • To assess the diagnostic utility of holoTC in children with H. pylori infection.

Main Methods:

  • Study included 30 children (6-15 years) with H. pylori infection and 26 controls.
  • Evaluated complete blood count, serum vitamin B12, folate, homocysteine, and plasma holoTC.
  • H. pylori infection diagnosed via C(14) urea breath test.

Main Results:

  • Children with H. pylori infection had significantly lower plasma holoTC levels before treatment.
  • Plasma holoTC levels normalized after H. pylori eradication therapy.
  • No significant changes were observed in total plasma vitamin B12 levels.

Conclusions:

  • H. pylori infection negatively impacts vitamin B12 status in children, indicated by reduced holoTC.
  • The effect on holoTC is reversible and resolves with successful H. pylori treatment.
  • HoloTC measurement may be a sensitive indicator of vitamin B12 status in pediatric H. pylori infection.
Abstract

Keywords:
Helicobacter pylorichildrenholotranscobalaminvitamin B12

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