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Diamine oxidase levels in different chronic urticaria phenotypes
A Daschner1, J González-Fernández2, A Valls1
1Servicio de Alergia, Instituto de Investigación Sanitaria-Hospital Universitario de la Princesa, Madrid, Spain.
Allergologia Et Immunopathologia
|May 19, 2015
Summary
Serum diamine oxidase (DAO) levels are higher in chronic urticaria (CU) patients with Anisakis sensitization (CU+). Lower DAO levels in CU+ may lead to urticaria exacerbation after fish consumption.
Area of Science:
- Immunology
- Gastroenterology
- Dermatology
Background:
- Diamine oxidase (DAO) is crucial for histamine metabolism.
- Chronic urticaria (CU) presents diverse clinical features.
- Anisakis sensitization-associated chronic urticaria (CU+) is a distinct phenotype.
Purpose of the Study:
- Analyze serum DAO levels in different CU phenotypes.
- Investigate the association between DAO levels and fish consumption habits.
Main Methods:
- Compared DAO levels in 35 CU+ patients, 39 CU- patients, and 19 controls.
- Assessed fish-eating frequency and fish intake-associated exacerbations (FIAE).
- Correlated DAO levels with immune responses (IgE, cytokines, lymphocyte proliferation).
Main Results:
- DAO levels were significantly higher in CU+ compared to CU- patients.
- CU+ patients with FIAE exhibited lower DAO levels.
- DAO levels correlated with specific Anisakis IgE and certain cytokines in CU+.
Conclusions:
- DAO levels in CU are influenced by fish consumption and IgE production in CU+.
- Lower enteric DAO availability may predispose CU+ patients to urticaria exacerbation after fish intake.
