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IFNA2: The prototypic human alpha interferon

Franciane Paul1, Sandra Pellegrini2, Gilles Uzé1

  • 1CNRS UMR 5235, University Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.

Gene
|May 19, 2015
PubMed

Keywords:
CytokineInterferon α2Type I interferon

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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