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Use of a Microsoft Excel based add-in program to calculate plasma sinistrin clearance by a two-compartment model
Sarah M L Steinbach1, Christopher P Sturgess2, Mark D Dunning3
1Small Animal Clinic (Internal Medicine), Justus - Liebig - University, Frankfurter Strasse 126, 35392 Giessen, Germany.
Abstract:
Assessment of renal function by means of plasma clearance of a suitable marker has become standard procedure for estimation of glomerular filtration rate (GFR). Sinistrin, a polyfructan solely cleared by the kidney, is often used for this purpose. Pharmacokinetic modeling using adequate software is necessary to calculate disappearance rate and half-life of sinistrin. The purpose of this study was to describe the use of a Microsoft excel based add-in program to calculate plasma sinistrin clearance, as well as additional pharmacokinetic parameters such as transfer rates (k), half-life (t1/2) and volume of distribution (Vss) for sinistrin in dogs with varying degrees of renal function.
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