Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world use of abbreviated dual antiplatelet therapy after percutaneous coronary intervention among patients with high bleeding risk: Are guidelines followed? Insights from the FRANCE-PCI registry.

Archives of cardiovascular diseases·2026
Same author

Multi-modal magnetic resonance imaging to assess cerebrovascular function in patients with atrial fibrillation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Combined hepatorenal denervation for hypertension and cardiometabolic disease: a first-in-human study.

European heart journal·2026
Same author

Heart Rate and Cardiovascular Outcomes in Post-Myocardial Infarction Patients Treated by β-Blockers: A Secondary Analysis of the ABYSS Trial.

Circulation·2026
Same author

Intravascular lithotripsy in comparison to rotational atherectomy for calcified lesions: the ICARE OFDI randomised trial.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026
Same author

Pacemaker recovery after permanent pacemaker implantation post-transcatheter aortic valve implantation: A sub-study of the LANDMARK trial.

International journal of cardiology·2026

Related Experiment Video

Updated: Apr 12, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

13.6K

Bioresorbable scaffolds on the bench.

John Ormiston1, Pascal Motreff, Olivier Darremont

  • 1Mercy Angiography, Auckland, New Zealand.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|May 19, 2015
PubMed
Summary

Bioresorbable scaffolds (BRS) offer advantages in bifurcations, but polymeric struts can fracture if over-inflated. Bench testing guides appropriate use and pressure limits for safe deployment of these novel coronary devices.

More Related Videos

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

16.6K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.6K

Related Experiment Videos

Last Updated: Apr 12, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

13.6K
Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

16.6K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.6K

Area of Science:

  • Cardiovascular Interventions
  • Biomaterials Science
  • Medical Device Engineering

Background:

  • Bioresorbable scaffolds (BRS) present unique advantages in treating coronary bifurcations, including potential release of the side branch (SB) from

Purpose of the Study:

  • To evaluate the mechanical behavior of polymeric BRS in simulated bifurcation lesions.
  • To determine safe pressure limits for balloon dilatation and post-dilatation strategies in bifurcations.
  • To inform interventional cardiologists on optimal BRS selection and deployment techniques.

Main Methods:

  • Bench testing of polymeric BRS in a 37°C water bath to simulate physiological conditions.
  • Assessment of scaffold distortion and fracture under various balloon dilatation pressures.
  • Evaluation of mini-kissing balloon post-dilatation (mini-KBPD) effects on scaffold integrity.

Main Results:

  • Polymeric BRS struts are susceptible to fracture when post-dilated beyond safe pressure limits.
  • Safe pressure threshold for SB dilatation of a 3.0 mm Absorb scaffold is 10 atm; for mini-KBPD, it is 5 atm.
  • Specific bifurcation stenting techniques like culotte, crush, and SKS may not be suitable for the Absorb scaffold.

Conclusions:

  • Bench testing is crucial for understanding BRS behavior in bifurcations and guiding clinical practice.
  • Careful attention to pressure limits during balloon dilatation is essential to prevent BRS fracture and ensure patient safety.
  • Interventional cardiologists must consider scaffold material properties and specific bifurcation anatomy when choosing and deploying BRS.