Related Experiment Video
Updated: Apr 12, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Recovery of knee function in the isolated MCL and combined ACL-MCL deficient knee
K Al-Hourani1, J Jefferies1, E Will1
1Department of Trauma and Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Background:
The MCL is the prime medial stabiliser of the knee and is a commonly injured structure which leads to valgus instability of the knee.
Objectives:
We aim to analyse differences in recovery of knee motion and muscle function over one year follow up in the isolated MCL and combined ACL-MCL injured knee. We hypothesized that combined ACL-MCL injuries lead to greater knee motion and muscle function deficits at 1 year.
Methods:
Isolated MCL (Group I) or combined ACL-MCL injuries (Group II) from 2006-2010 were included. Those with a previous MCL injury, injury to contralateral limb or presenting 2 weeks post-injury were excluded. At certain outpatient follow up intervals, we recorded pre-determined parameters of knee function. Follow-up was at weeks 2, 6, 12, 26, 52.
Results:
The cohort included 82 patients (54 males:28 females) with a mean age of 32 (range 16-56). Group II showed a deficit in Total Range of Movement (TROM) and flexion at 6 month follow up (p < 0.05). Group II showed an extension deficit at week 2 (p < 0.05). The Peak Torque Deficit (PTD) and Average Power Deficit (APD) improved for quadriceps and hamstrings across all follow up intervals (p > 0.05).
Conclusion:
There is a TROM and flexion deficit at 6 months in group II, resolving by 1 year. There was no difference in PTD or APD in either group.
More Related Videos
05:07Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction
Published on: March 1, 2024
06:27Author Spotlight: Investigating Early Events and Long-Term Effects of ACL Injuries for Osteoarthritis Progression
Published on: September 29, 2023