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Related Experiment Videos

[Antiplatelet aggregation effect of Andregraphis paniculata].

H Tan, J Z Tang

    Zhong Xi Yi Jie He Za Zhi = Chinese Journal of Modern Developments in Traditional Medicine
    |September 1, 1989
    PubMed
    Summary

    Andrographis paniculata (AP) extract significantly inhibits platelet aggregation and enhances fibrinolysis, suggesting its potential as an antithrombogenic agent for arterial diseases.

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    Area of Science:

    • Pharmacology
    • Natural Products
    • Hemostasis

    Context:

    • Platelet aggregation plays a crucial role in arterial thrombotic diseases.
    • Andrographis paniculata (AP) is a medicinal herb with potential therapeutic properties.

    Purpose:

    • To investigate the antiplatelet aggregation and profibrinolytic effects of Andrographis paniculata (AP).
    • To evaluate the in vitro and in vivo efficacy of AP in modulating platelet function and coagulation.

    Summary:

    • Crude AP extract significantly inhibited ADP-induced platelet aggregation in vitro and in vivo, demonstrating a dose-dependent effect.
    • AP also exhibited a significant activating effect on fibrinolysis, shortening euglobulin lysis time.
    • The study assessed AP's influence on coagulation and thrombelastogram parameters.

    Impact:

    • Andrographis paniculata shows promise as an antithrombogenic agent.
    • AP may be beneficial in the prevention and treatment of arterial thrombotic diseases.

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