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Membranoproliferative glomerulonephritis associated with an Epstein-Barr virus infection

Lazarus Karamadoukis1, Tibor Toth2, Charlie Tomson1

  • 1The Richard Bright Renal Unit.

NDT Plus
|May 19, 2015
PubMed

Insights

Type 1 membranoproliferative glomerulonephritis (MPGN) linked to Epstein-Barr virus (EBV) infection can present with nephrotic syndrome. Treatment with an angiotensin 2-receptor blocker led to resolution, suggesting a potentially benign course for EBV-associated MPGN.

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Type 1 membranoproliferative glomerulonephritis (MPGN) is an immune complex-mediated kidney disease.
  • MPGN has been associated with various viral infections like hepatitis C, B, G, HIV, and Hantavirus.

Purpose of the Study:

  • To report a case of type 1 MPGN with nephrotic syndrome potentially caused by a primary Epstein-Barr virus (EBV) infection.
  • To investigate the clinical course and treatment outcome of EBV-associated MPGN.

Main Methods:

  • Case report describing a patient with type 1 MPGN and nephrotic syndrome.
  • Clinical evaluation, evidence of primary EBV infection, and treatment with an angiotensin 2-receptor blocker.

Main Results:

  • The patient presented with type 1 MPGN in native kidneys and nephrotic syndrome.
  • Strong evidence suggested a primary Epstein-Barr virus (EBV) infection as the causative agent.
  • Nephrotic syndrome resolved within six months of treatment with an angiotensin 2-receptor blocker.

Conclusions:

  • Acute Epstein-Barr virus (EBV) infection may play a causative role in type 1 MPGN presenting with nephrotic syndrome.
  • MPGN associated with acute EBV infection may follow a relatively benign clinical course with appropriate treatment.
Keywords:
Epstein–Barr virusmembranoproliferative glomerulonephritisnephrotic syndrome

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