Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

968
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
968
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

498
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
498
Dialysis01:27

Dialysis

2.1K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
2.1K
Dialysis01:15

Dialysis

2.3K
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
2.3K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

1.8K
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
1.8K
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

728
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
728

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy.

The Journal of clinical investigation·2026
Same author

A case of early pregnancy pulmonary embolism following mifepristone administration: a call for increased pharmacovigilance and research.

Blood transfusion = Trasfusione del sangue·2026
Same author

Sudden bilateral ocular pain, conjunctival redness and blurred vision with halos at hemodialysis start: an eye of attention for the nephrologist! Lessons for the Clinical Nephrologist.

Journal of nephrology·2026
Same author

DPP-4 inhibitors in current diabetes care: their foundational role in treating to target.

Diabetes research and clinical practice·2026
Same author

Multidrug-Resistant Gram-Negative Urinary Tract Infections (UTIs) Increase the Risk of Rejection, CMV Viremia, and Graft Loss After Kidney Transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Precision Diagnosis in APOL1 Kidney Disease With the p.N264K M1 Protective Variant.

JAMA network open·2026

Related Experiment Video

Updated: Apr 12, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
07:38

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

9.8K

Sustained low-efficiency dialysis (SLED) for acute lithium intoxication.

Enrico Fiaccadori1, Umberto Maggiore1, Elisabetta Parenti1

  • 1Dipartimento di Clinica Medica & Nefrologia , Universita' degli Studi di Parma , Parma , Italy.

NDT Plus
|May 19, 2015
PubMed
Summary

Sustained low-efficiency dialysis (SLED) effectively treated acute lithium intoxication, rapidly improving neurologic symptoms. This method minimized lithium rebound, offering a safe and efficient alternative for managing severe lithium overdose cases.

Keywords:
bipolar disorderdialysisdrug toxicitylithiumpsychotropic drugs

More Related Videos

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.5K
Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

12.2K

Related Experiment Videos

Last Updated: Apr 12, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
07:38

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

9.8K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.5K
Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

12.2K

Area of Science:

  • Nephrology
  • Toxicology
  • Emergency Medicine

Background:

  • Acute lithium intoxication can lead to severe neurological and cardiac complications.
  • Lithium is efficiently removed by extracorporeal methods like renal replacement therapy (RRT).
  • Conventional hemodialysis may be limited by rebound phenomena in lithium intoxication.

Purpose of the Study:

  • To evaluate the efficacy and safety of sustained low-efficiency dialysis (SLED) for acute lithium intoxication.
  • To assess the impact of SLED on lithium serum levels and patient recovery.
  • To investigate the rebound phenomenon after SLED in lithium overdose.

Main Methods:

  • A case report of a patient with acute lithium carbonate ingestion.
  • Treatment involved 8 hours of SLED with specific blood and dialysate flow rates.
  • Monitoring of lithium serum levels, neurological status, and renal function.

Main Results:

  • Lithium serum levels decreased by 86% during SLED treatment.
  • Patient's mental status improved significantly within 4 hours of SLED initiation.
  • No significant lithium rebound was observed after SLED completion.
  • Renal function recovered fully, and the patient was discharged after 3 days.

Conclusions:

  • Sustained low-efficiency dialysis (SLED) is a safe and effective treatment for acute lithium intoxication.
  • SLED demonstrates efficient lithium clearance and minimizes rebound effects.
  • This case highlights SLED as a viable therapeutic option for severe lithium overdose.