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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Acute renal failure after treatment with sunitinib in a patient with multiple myeloma

Nelson Leung1, Nathan A Saucier1, Steven R Zeldenrust2

  • 1Division of Nephrology and Hypertension.

NDT Plus
|May 19, 2015
PubMed

Insights

Sunitinib, a cancer drug, can cause kidney damage. This report details the first case of acute tubular necrosis, a severe kidney injury, in a multiple myeloma patient treated with sunitinib.

Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Background:

  • Sunitinib is an oral multi-targeted tyrosine kinase inhibitor approved for advanced renal cell carcinoma.
  • Its known targets include fetal liver tyrosine kinase receptor 3 (FLT3) and vascular endothelial growth factor receptor (VEGFR).
  • While clinical trials did not report renal toxicity, some patients developed a pre-eclampsia-like syndrome.

Observation:

  • A patient with multiple myeloma was treated with sunitinib.
  • The patient developed acute tubular necrosis.

Findings:

  • This is the first reported case of acute tubular necrosis in a multiple myeloma patient receiving sunitinib.
  • The mechanism linking sunitinib to acute tubular necrosis in this context requires further investigation.

Implications:

  • This case highlights a potential, previously unreported renal adverse effect of sunitinib.
  • Clinicians should be vigilant for renal toxicity, including acute tubular necrosis, in multiple myeloma patients treated with sunitinib.
  • Further research is warranted to elucidate the pathophysiology and incidence of sunitinib-induced acute tubular necrosis.
Keywords:
acute renal failuredrug toxicitysunitinib

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