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Acetazolamide may provoke cyclosporine toxicity-a case report
Päivi Ruokoniemi1, Risto Tertti2, Pia Paalosmaa-Puusa3
1Department of Clinical Pharmacology , University of Helsinki , Helsinki , Finland.
Abstract:
We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon. The follow-up of cyclosporine concentrations is necessary, and the reduction of the cyclosporine dose is likely to be needed when patients taking cyclosporine are started with acetazolamide.
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