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Membranous nephropathy associated with gastrointestinal stromal tumour: a case report
Adela Cimic1, Stephen O Pastan2, Vanesa Bijol1
1Department of Pathology , Emory University Hospital.
Abstract:
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in older adults. The association of MN with neoplasia has been controversial, but several recent studies have shown increase incidence of cancer in patients with MN [1]. We report a case of a 49-year-old male with severe nephrotic syndrome and concomitant jejunal gastrointestinal stromal tumour (GIST). The combination of preoperative Imatinib mesylate chemotherapy and tumour excision was followed by complete resolution of proteinuria within 19 months, without specific treatment for MN. An association between MN and GIST has never previously been reported in the literature.
Insights
Membranous nephropathy (MN) is linked to cancer. A patient with MN and a jejunal gastrointestinal stromal tumour (GIST) experienced proteinuria resolution after GIST treatment, suggesting a potential association.
Area of Science:
- Nephrology
- Gastroenterology
- Oncology
Background:
- Membranous nephropathy (MN) is a primary cause of nephrotic syndrome, particularly in older adults.
- The link between MN and malignancy is increasingly recognized, though controversial.
- Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms of the gastrointestinal tract.
Observation:
- A 49-year-old male presented with severe nephrotic syndrome.
- The patient was diagnosed with a jejunal gastrointestinal stromal tumor (GIST).
- This represents the first reported case associating MN with GIST.
Findings:
- The patient received preoperative Imatinib mesylate chemotherapy followed by surgical tumor excision.
- Complete resolution of proteinuria was observed within 19 months post-treatment.
- No specific treatment for membranous nephropathy was administered.
Implications:
- This case suggests a potential paraneoplastic link between membranous nephropathy and gastrointestinal stromal tumors.
- Further research is warranted to explore the association between MN and GIST.
- Understanding this association may influence diagnostic and treatment strategies for patients with unexplained nephrotic syndrome.
