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Updated: Apr 12, 2026

Whole Body Vibration Methods with Survivors of Polio
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Treatment for postpolio syndrome.

Fieke Sophia Koopman1, Anita Beelen, Nils Erik Gilhus

  • 1Department of Rehabilitation, University of Amsterdam Academic Medical Center, PO Box 22660, Amsterdam, North Holland, Netherlands, 1100 DD.

The Cochrane Database of Systematic Reviews
|May 19, 2015
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Summary

Evidence for postpolio syndrome (PPS) treatments is limited. While some interventions like IVIg, lamotrigine, muscle strengthening, and magnetic fields show potential, more high-quality research is needed to confirm their effectiveness for PPS patients.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Postpolio syndrome (PPS) affects survivors of paralytic poliomyelitis, causing neuromuscular symptoms and functional decline.
  • Established pharmacological and rehabilitation treatments for PPS are lacking.
  • This review updates previous findings on PPS interventions.

Purpose of the Study:

  • To systematically review evidence from randomized and quasi-randomized controlled trials for PPS treatments.
  • To compare pharmacological and non-pharmacological interventions against placebo, usual care, or no treatment.

Main Methods:

  • Searched multiple databases (Cochrane, MEDLINE, EMBASE, etc.) and trial registers up to July 2014.
  • Included randomized and quasi-randomized trials of any PPS treatment.
  • Primary outcome: self-perceived activity limitations; secondary outcomes: muscle strength, endurance, fatigue, pain, and adverse events.

Main Results:

  • 13 studies (10 pharmacological, 3 non-pharmacological) involving 675 participants were reviewed.
  • Intravenous immunoglobulin (IVIg) showed no significant benefit for activity limitations and had minor adverse events.
  • Lamotrigine, muscle strengthening, and static magnetic fields showed potential benefits for pain, fatigue, or strength but require further study.
  • Modafinil, pyridostigmine, amantadine, prednisone, and climate-based rehabilitation were found to be ineffective.

Conclusions:

  • Insufficient high-quality data and a lack of randomized studies prevent definitive conclusions on PPS interventions.
  • IVIg, lamotrigine, muscle strengthening, and static magnetic fields may offer benefits but need further investigation.
  • More robust research is essential to determine the true efficacy and clinical significance of potential PPS treatments.