[State of the art of nerve fibrin adhesion]

Although in use for over 15 years, commercially available fibrin adhesives are still regarded with scepticism when they are used for nerve anastomosing. We therefore studied the fibrosing potential of the two presently available fibrin adhesives by determining the amount of connective tissue in the anastomoses using light microscopy. In addition, regeneration was examined by electrophysiology. No significant differences were detected when 1000 KIE aprotinin and 3 IU thrombin were used. The amount of connective tissue was 33%, and regeneration was proven beyond doubt.