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Updated: Apr 12, 2026

Single Molecule Fluorescence Microscopy on Planar Supported Bilayers

Single Molecule Fluorescence Microscopy on Planar Supported Bilayers

Published on: October 31, 2015

Photon small-field measurements with a CMOS active pixel sensor.

F Jiménez Spang¹, I Rosenberg, E Hedin

¹Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.

Physics in Medicine and Biology

|May 19, 2015

Summary

This summary is machine-generated.

CMOS active pixel sensors show high spatial resolution for measuring small photon beams. These sensors accurately assess beam profiles and output factors, proving promising for advanced dosimetry applications.

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Area of Science:

Medical Physics
Radiation Detection
Semiconductor Devices

Background:

Accurate dosimetry of small photon beams is crucial for modern radiotherapy.
Traditional detectors face challenges with high spatial resolution requirements.
CMOS active pixel sensors offer potential for improved small field dosimetry.

Purpose of the Study:

To evaluate the dosimetric performance of CMOS active pixel sensors (APS) for small photon beam measurements.
To compare the sensor's measurements against established dosimetry methods.
To assess the sensor's suitability for clinical dosimetry applications.

Main Methods:

Utilized a CMOS APS with a 520x520 pixel array (25 µm pitch).
Measured dosimetric parameters including beam profiles, penumbrae, field size, and output factors.
Compared sensor data with ionization chambers, film detectors, and GEANT4 Monte Carlo simulations.

Main Results:

Achieved high spatial resolution for accurate profile and penumbrae measurements, even under lateral electronic disequilibrium.
Field size and penumbrae measurements agreed within 5.4% and 2.2% with film, respectively.
Agreed within 1.0% with ionization chambers for tissue-phantom ratios and showed good agreement for output factors with ionization chambers and Monte Carlo simulations.

Conclusions:

CMOS active pixel sensors demonstrate excellent dosimetric performance for small photon beams.
The high spatial resolution enables accurate characterization of beam parameters.
These sensors are a promising tool for developing advanced dosimetry systems in radiation therapy.