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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
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Sonication-Assisted Layer-by-Layer Assembly for Low Solubility Drug Nanoformulation.

Ana C Santos1,2, Pravin Pattekari3, Sandra Jesus1,2

  • 1†Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Faculty of Medicine, Pólo I, First Floor, 3000-504 Coimbra, Portugal.

ACS Applied Materials & Interfaces
|May 19, 2015
PubMed
Summary
This summary is machine-generated.

Sonication-assisted layer-by-layer self-assembly effectively encapsulates ibuprofen (IBF) into nanoparticles. This nanoencapsulation technique offers a stable drug delivery system with controlled release, improving biopharmaceutical properties.

Keywords:
colloidcontrolled releaseelectrostatic interactionslayer-by-layer self-assemblyoral deliverywashless

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Low solubility drugs present formulation and delivery challenges.
  • Layer-by-layer (LbL) self-assembly is a versatile nanoencapsulation technique.
  • Sonication enhances the LbL process for improved drug delivery.

Purpose of the Study:

  • To develop and characterize ibuprofen (IBF) nanoparticles using sonication-assisted LbL self-assembly.
  • To evaluate the entrapment efficiency, stability, and in vitro release of IBF from LbL nanoparticles.
  • To assess the biocompatibility of the developed nanoencapsulation system.

Main Methods:

  • Utilized a washless, top-down LbL technique with poly(allylamine hydrochloride) (PAH) and polystyrenesulfonate (PSS).
  • Prepared IBF nanoparticles with varying numbers of PAH/PSS bilayers (2.5, 5.5, 7.5).
  • Characterized nanoparticle size, polydispersity index (PDI), zeta potential, and IBF entrapment efficiency via HPLC.

Main Results:

  • 7.5 bilayer IBF nanoparticles exhibited optimal size (127.5 nm), PDI (0.24), and high zeta potential (+32.7 mV).
  • Achieved a high IBF entrapment efficiency of 72.1%.
  • Demonstrated biocompatibility through in vitro MTT assay and controlled drug release over 7 days.

Conclusions:

  • PAH/PSS-LbL nanoparticles are a promising system for encapsulating and delivering low solubility drugs like ibuprofen.
  • The LbL technique allows for tunable drug release profiles based on the number of bilayers.
  • This nanoencapsulation approach can significantly enhance the biopharmaceutical parameters of poorly soluble drugs.