Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Drugs for Treatment of Constipation-Predominant IBS

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Therapeutic Impact on Quality of Life in Adult Patients With Chronic Intestinal Pseudo-obstruction: A Multicenter, Cohort Study.

Journal of neurogastroenterology and motility·2026

Same author

<italic>Bifidobacterium bifidum</italic> G9-1 and Quality of Life in Chronic Constipation: A Multicenter, Double-Blind, Randomized Controlled Trial.

Digestion·2026

Same author

Novel antiemetic effect of naldemedine in patients initiating opioids for cancer pain: a secondary analysis of a randomized clinical trial.

The oncologist·2026

Same author

Erratum: Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025

Same author

Efficacy and safety of linaclotide in treatment-resistant chronic constipation: A multicenter, open-label study.

Neurogastroenterology and motility·2024

Same author

Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2024

Search research articles

Related Experiment Video

Updated: Apr 12, 2026

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

[Chronic intestinal pseudo-obstruction].

Hidenori Ohkubo, Yumi Inoh, Akiko Fuyuki

Nihon Rinsho. Japanese Journal of Clinical Medicine

|May 20, 2015

Summary

This summary is machine-generated.

Chronic intestinal pseudo-obstruction (CIPO) is a rare digestive disease causing symptoms of obstruction without a mechanical cause. Early diagnosis and management are crucial for improving patient outcomes and nutritional status.

More Related Videos

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Related Experiment Videos

Last Updated: Apr 12, 2026

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Area of Science:

Gastroenterology
Digestive Diseases
Rare Diseases

Context:

Chronic intestinal pseudo-obstruction (CIPO) presents as a severe digestive disorder mimicking mechanical intestinal obstruction.
Pathophysiology involves impaired intestinal motility due to issues with smooth muscle, enteric nervous system, and interstitial cells of Cajal (ICC).
Complications include malabsorption, bacterial translocation, malnutrition, and sepsis.

Purpose:

To discuss the challenges in diagnosing and managing Chronic Intestinal Pseudo-obstruction (CIPO).
To highlight the development and revision of Japanese diagnostic criteria for CIPO.
To introduce cine-MRI as a potential non-invasive diagnostic tool.

Summary:

Management focuses on nutritional support and symptom reduction, with dietary modifications for mild cases and home parenteral nutrition (HPN) or decompression for severe cases.
Established diagnostic methods like manometry and scintigraphy are not widely available in Japan, necessitating alternative approaches.
Japanese diagnostic criteria were proposed in 2009 and revised in 2014, with cine-MRI emerging as a promising non-invasive diagnostic method.

Impact:

Facilitates earlier and more accurate diagnosis of CIPO, particularly by general physicians in Japan.
CINE-MRI offers a non-invasive diagnostic alternative, potentially improving patient management.
The disease's recognition as a Specified Rare and Intractable Disease in Japan provides public funding and support.