The value of computed tomography in the diagnosis of amiodarone-induced pulmonary toxicity

Amiodarone hydrochloride (Cordarone) is an effective antiarrhythmic drug which can cause a potentially fatal pneumonitis. The clinical diagnosis is difficult and investigation non-specific. Narrow section computed tomography (CT) was performed in nine patients who developed new respiratory symptoms during treatment with amiodarone. All had chest radiographs prior to CT, six had respiratory function tests and four had serum amiodarone estimations. High density basal peripheral pleuro-parenchymal lesions were seen in four of the nine patients. These appearances were compatible with those previously detected in other pulmonary interstitial lung diseases. We suggest that CT is a useful investigation in patients with suspected amiodarone pulmonary toxicity.