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Vaccine coverage in CF children: A French multicenter study
Insights
Vaccine coverage for mandatory and recommended vaccines is low in children with cystic fibrosis (CF), indicating a need for improved immunization strategies in this vulnerable population.
Area of Science:
- Pediatric Infectious Diseases
- Pulmonology
- Immunology
Background:
- Low vaccine coverage is a concern in chronic disease patients.
- Data on vaccination status in cystic fibrosis (CF) patients are limited.
- Optimizing care for CF patients requires understanding their immunization levels.
Purpose of the Study:
- To assess vaccination coverage for mandatory and recommended vaccines in cystic fibrosis patients.
- To compare vaccine coverage in CF patients to the general population.
- To identify gaps in immunization for CF care optimization.
Main Methods:
- Prospective study utilizing data from the "MucoFlu" study (2009).
- Data collected from 5 cystic fibrosis centers in the Paris metropolitan area.
- Vaccination status from health booklets compared to general population data.
Main Results:
- 134 CF children were included in the analysis.
- Insufficient coverage for mandatory vaccines (DTPCaHi, pneumococcal, BCG, MMR, hepatitis B) at 1 year, with no catch-up.
- Low coverage for recommended CF vaccines: hepatitis A, non-conjugate pneumococcal, and varicella.
- High coverage for seasonal influenza (66%) and pandemic flu (91%) in 2009.
Conclusions:
- Significant deficits in vaccine coverage exist for both routine and CF-specific immunizations in this patient group.
- The findings highlight a critical need for enhanced vaccination strategies in cystic fibrosis care.
- Addressing these coverage gaps is essential for improving health outcomes in children with CF.
Backgrounds:
Recent reports have pointed the low vaccine coverage in patients with chronic diseases. Data are lacking in patients with cystic fibrosis (CF). Gaining more information on coverage both for mandatory vaccines and those more specifically recommended would help to optimize care of these patients.
Methods:
Data were extracted from the "MucoFlu" study, which was a prospective study performed in 2009 in the 5 cystic fibrosis centers of the Paris metropolitan area. Data on mandatory and recommended vaccines in CF were collected in the health booklet and compared to the coverage of the general population.
Results:
A total of 134 CF children were included. Vaccination coverage for mandatory vaccines was insufficient (DTPCaHi, conjugate pneumococcal, BCG, MMR and hepatitis B) at 1year of age with no catching-up with age in contrast to the general population. Approximately 66% of the children had immunization for seasonal influenza and 91% for 2009 pandemic flu. Coverage for vaccines specifically recommended in CF was low for hepatitis A, non conjugate pneumococcal and varicella.
Conclusion:
This study shows a defect in vaccine coverage for both routine immunization and vaccines more specifically recommended in CF.
