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Pericardial Involvement in IgG4-related Disease
Kiyoo Mori1, Kazunori Yamada, Tetsuo Konno
1Department of Internal Medicine, Houju Memorial Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|May 20, 2015
Summary
This case report highlights early-stage pericardial involvement in immunoglobulin G4 (IgG4)-related disease associated with autoimmune pancreatitis. Corticosteroid treatment effectively resolved pericardial thickening, demonstrating a key finding for IgG4-related disease management.
Area of Science:
- Immunology
- Gastroenterology
- Cardiology
Background:
- Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic fibroinflammatory condition affecting multiple organs.
- Pericardial involvement in IgG4-RD, particularly chronic constrictive pericarditis, is rarely reported.
- Autoimmune pancreatitis is a common manifestation of IgG4-RD.
Observation:
- A 65-year-old man presented with pericardial involvement secondary to autoimmune pancreatitis.
- Chest CT imaging revealed significant pericardial thickening.
- The patient received corticosteroid therapy for the condition.
Findings:
- The pericardial thickening demonstrated a complete resolution following corticosteroid treatment.
- This case represents the first reported instance of early-stage IgG4-related disease presenting with pericardial involvement.
- The findings underscore the potential for IgG4-RD to manifest with cardiac complications.
Implications:
- Early recognition of pericardial complications in autoimmune pancreatitis is crucial for timely diagnosis and treatment of IgG4-related disease.
- Chest CT imaging serves as a valuable tool for diagnosing and monitoring pericardial lesions in IgG4-RD.
- This case expands the understanding of IgG4-RD manifestations and emphasizes the importance of a multidisciplinary approach in managing complex cases.
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