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Related Experiment Video

Updated: Apr 12, 2026

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[Sentinel lymph node-multicentric and multifocal tumors: a valid technique?].

G Houvenaeghel1, M Cohen1, C Jauffret Fara1

  • 1Institut Paoli-Calmettes et CRCM, Aix-Marseille université, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.

Gynecologie, Obstetrique & Fertilite
|May 20, 2015
PubMed
Summary
This summary is machine-generated.

Sentinel lymph node biopsy is a valid option for multifocal or multicentric breast cancer patients with negative sentinel lymph nodes. This approach avoids the need for complementary axillary lymph node dissection.

Keywords:
Breast cancerCancer du seinGanglion sentinelleMulticentricMulticentriqueMultifocalSentinel node

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Sentinel lymph node biopsy (SLNB) is established for unifocal breast cancer (T1-2 N0).
  • SLNB without completion axillary lymph node dissection (ALND) is contraindicated for multifocal/multicentric tumors.
  • Evidence is needed to evaluate SLNB in these complex cases.

Purpose of the Study:

  • To determine if SLNB without completion ALND is a valid option for multifocal/multicentric breast cancer.
  • To analyze existing literature on SLNB outcomes in these patient groups.
  • To assess the safety and efficacy of omitting completion ALND when SLNB is negative.

Main Methods:

  • Systematic literature review and meta-analysis.
  • Inclusion of studies reporting SLNB outcomes for multifocal/multicentric breast cancer.
  • Analysis of recurrence rates and survival data based on SLNB status and completion ALND.

Main Results:

  • Sentinel lymph node biopsy can be a valid option for multifocal/multicentric breast cancer.
  • Negative sentinel lymph nodes in these cases may obviate the need for completion ALND.
  • Further research is required to confirm these findings and establish definitive guidelines.

Conclusions:

  • Sentinel lymph node biopsy without completion axillary lymph node dissection appears feasible for select multifocal/multicentric breast cancer patients.
  • Careful patient selection and adherence to oncologic principles are crucial.
  • This approach may reduce morbidity associated with unnecessary axillary dissection.