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Allergic contact dermatitis from croconazole hydrochloride
M Shono1, K Hayashi, R Sugimoto
1Division of Dermatology, Saiseikai Kawaguchi General Hospital, Saitama, Japan.
Contact Dermatitis
|October 1, 1989
Summary
Contact sensitivity to croconazole hydrochloride, an imidazole antimycotic, has been identified in six patients. Three patients also showed cross-sensitivity to sulconazole nitrate, highlighting potential drug interactions.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Toxicology
Background:
- Croconazole hydrochloride is an imidazole antimycotic agent introduced in Japan in 1986.
- Available as 1% gel and cream formulations.
- Antimycotic agents are widely used for fungal infections.
Observation:
- Six cases of contact sensitivity to croconazole hydrochloride were reported.
- Patients presented with allergic contact dermatitis.
- Patch testing was performed on sensitized patients.
Findings:
- All six sensitized patients reacted to croconazole hydrochloride in patch tests at concentrations as low as 0.5% to 0.1% pet.
- Three patients exhibited cross-sensitivity to sulconazole nitrate.
- A total of 12 cases of allergic contact dermatitis to croconazole hydrochloride have been reported in Japan.
Implications:
- Healthcare providers should be aware of the potential for contact sensitivity to croconazole hydrochloride.
- Cross-sensitivity to sulconazole nitrate may occur in some patients.
- This highlights the importance of careful prescribing and patient monitoring for adverse reactions to topical antimycotics.