Allergic contact dermatitis from croconazole hydrochloride

We report 6 cases of contact sensitivity to croconazole hydrochloride, a new imidazole antimycotic drug introduced to the Japanese market in 1986, and available as 1% gel and cream. 6 sensitized patients reacted on patch testing to croconazole hydrochloride down to 0.5 to 0.1% pet, and 3 appeared to be cross-sensitized to sulconazole nitrate. In Japan, allergic contact dermatitis to this drug has now been detected in 12 cases, including our own 6. Prescribers should be aware of contact sensitivity to this drug.