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FK506-Binding Proteins and Their Diverse Functions.
1Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. yuj5@pitt.edu.
FK506 binding proteins (FKBPs) are conserved eukaryotic proteins. This review summarizes FKBP structures and their diverse roles in cellular functions like protein folding and signaling.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- FK506 binding proteins (FKBPs) are a conserved family of eukaryotic proteins.
- FKBP12, the prototype, binds immunosuppressive drugs FK506 and rapamycin.
- FKBPs contain peptidyl prolyl isomerase (PPIase) domains crucial for their function.
Purpose of the Study:
- To provide a comprehensive summary of FKBP structures.
- To review the diverse cellular functions of FKBPs in mammalian cells.
Main Methods:
- Literature review of existing research on FKBP family proteins.
- Analysis of structural and functional data for mammalian FKBPs.
Main Results:
- FKBPs are involved in essential cellular processes including protein folding, signaling, apoptosis, and transcription.
- They act as molecular switches by binding to and altering the conformation of target proteins.
Conclusions:
- FKBP family proteins exhibit diverse structures and play critical roles in cellular regulation.
- Understanding FKBP functions is key to comprehending various biological processes.
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