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Hyperlipidemia in rheumatoid arthritis patients in Saudi Arabia. Correlation with C-reactive protein levels and

Suzan M Attar1

  • 1Department of Internal Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail. suzan_attar@hotmail.com.

Saudi Medical Journal
|May 20, 2015
PubMed

Insights

Hyperlipidemia is prevalent in Saudi Arabian rheumatoid arthritis (RA) patients, significantly linked to elevated C-reactive protein (CRP) and disease activity. This highlights the need for increased awareness of lipid disorders in active RA.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Clinical Biochemistry

Background:

  • Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with an increased risk of cardiovascular complications.
  • Hyperlipidemia is a known risk factor for cardiovascular disease, but its prevalence and associations in RA patients in Saudi Arabia require further investigation.

Purpose of the Study:

  • To determine the prevalence of hyperlipidemia in rheumatoid arthritis patients in Saudi Arabia.
  • To investigate the relationship between hyperlipidemia, C-reactive protein (CRP) levels, and disease activity in these patients.

Main Methods:

  • A cross-sectional study was conducted on 180 RA patients at King Abdulaziz University Hospital, Saudi Arabia.
  • Lipid profiles were measured after overnight fasting.
  • Associations between lipid profiles, CRP levels, and disease activity (28-Joint Disease Activity Score) were analyzed.

Main Results:

  • A high prevalence of hyperlipidemia was observed, with elevated total cholesterol in 55.1% and low-density lipoprotein cholesterol in 51.2% of patients.
  • A significant association was found between increased total cholesterol and higher CRP levels (p=0.002).
  • A positive correlation was detected between total cholesterol and RA disease activity (r=0.23, p=0.036).

Conclusions:

  • Hyperlipidemia is common in Saudi RA patients and significantly associated with elevated CRP levels and disease activity.
  • These findings underscore the importance of monitoring lipid profiles in RA patients, particularly during periods of active disease.
  • Increased awareness among healthcare professionals is crucial for managing hyperlipidemia in active RA.
Abstract

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