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Impaired aortic function in patients with coeliac disease

Cenk Sari, Ahmet Göktug Ertem1, Sevil Sari

  • 1Department of Cardiology, Ankara Penal Instution Campus State Hospital. agertem@hotmail.com.

Kardiologia Polska
|May 20, 2015
PubMed

Insights

Patients with coeliac disease (CD) show impaired aortic function, including reduced aortic strain and distensibility, and increased aortic stiffness. This suggests a higher risk of atherosclerosis and cardiovascular events in individuals with CD.

Area of Science:

  • Cardiovascular Physiology
  • Gastroenterology
  • Immunology

Background:

  • Coeliac disease (CD) is an autoimmune disorder affecting the small intestine.
  • Aortic function, encompassing aortic stiffness index, strain, and distensibility, is a known predictor of atherosclerosis.
  • The relationship between CD and cardiovascular health, specifically aortic function, requires further investigation.

Purpose of the Study:

  • To investigate the association between key indicators of aortic function and coeliac disease.
  • To determine if CD is linked to altered aortic stiffness, strain, or distensibility.

Main Methods:

  • Echocardiography was used to assess aortic distensibility, strain, and stiffness index.
  • Serological markers for autoimmune activity were measured in 36 CD patients and 35 controls.
  • Statistical analysis was performed to identify correlations between CD and aortic function parameters.

Main Results:

  • Patients with CD exhibited significantly lower aortic strain and distensibility compared to controls.
  • A significantly higher aortic stiffness index was observed in CD patients.
  • Coeliac disease was identified as an independent predictor of all measured aortic function parameters.

Conclusions:

  • Deteriorated aortic function, indicative of subclinical atherosclerosis, was demonstrated in CD patients via echocardiography.
  • Impaired aortic function in CD patients highlights a potential increased risk for cardiovascular events.
  • Enhanced collaboration between cardiology and gastroenterology, along with increased awareness among healthcare providers and patients, is crucial for managing cardiovascular risk in CD.
Abstract

Keywords:
aortic functioncoeliac diseaseechocardiography

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