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Updated: Apr 12, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Ageing with HIV: a multidisciplinary review.

A Calcagno1, S Nozza2, C Muss3

  • 1Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy. andrea.calcagno@unito.it.

Infection
|May 20, 2015
PubMed
Summary

Caring for aging HIV patients involves managing frailty and comorbidities. Combining low-toxicity drugs with healthy lifestyle choices like nutrition and exercise is key for better outcomes in HIV-positive individuals.

Keywords:
AgeingComorbiditiesFrailtyHIVImmune senescencePharmacokineticsToxicity

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Area of Science:

  • Geriatrics
  • Infectious Diseases
  • Pharmacology

Background:

  • Human Immunodeficiency Virus (HIV) infection is now a chronic condition due to effective antiretroviral therapy.
  • A growing population of HIV-positive individuals are aging, presenting unique healthcare challenges.

Purpose of the Study:

  • To review the multifaceted care requirements for aging HIV-positive patients.
  • To discuss therapeutic strategies for frailty in both HIV-positive and negative aging populations.

Main Methods:

  • Literature review of frailty definitions, prevalence, and risk factors in aging HIV patients.
  • Analysis of age-related pharmacokinetic changes and antiretroviral toxicities.
  • Examination of therapeutic interventions for frailty.

Main Results:

  • Aging HIV patients face complex health issues, including frailty and increased risk of comorbidities.
  • Pharmacokinetic alterations and antiretroviral drug toxicities are significant considerations in older HIV-positive individuals.
  • Therapeutic approaches for frailty are being explored for both HIV-positive and negative aging populations.

Conclusions:

  • Optimizing care for aging HIV-positive individuals requires a comprehensive approach.
  • Minimizing drug toxicity and promoting healthy lifestyle behaviors are crucial.
  • A combination of judicious pharmacotherapy and lifestyle interventions offers the best practice for aging HIV-positive subjects.