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Tangential Flow Ultrafiltration: A “Green” Method for the Size Selection and Concentration of Colloidal Silver Nanoparticles

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Nanofiltration to remove microparticles and decrease the thrombogenicity of plasma: in vitro feasibility assessment.

Ming-Li Chou¹, Liang-Tzung Lin^1,2, David Devos³

¹Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

|May 20, 2015

Summary

This summary is machine-generated.

Nanofiltration effectively removes procoagulant microparticles (MPs) from plasma, significantly reducing its in vitro thrombogenicity. This process preserves essential coagulation factors and hemostatic activity.

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Area of Science:

Biomedical Engineering
Hematology
Biophysics

Background:

Plasma contains procoagulant microparticles (MPs) that contribute to in vitro thrombogenicity.
Removing MPs may reduce plasma thrombogenicity while preserving hemostatic function.

Purpose of the Study:

To evaluate the efficacy of 75-nm nanofiltration for removing MPs from plasma.
To assess the impact of MP removal on plasma in vitro thrombogenicity and coagulation factor activity.

Main Methods:

Nanofiltration of leukoreduced plasma using a 75-nm hollow-fiber membrane filter.
Assessed plasma quality via coagulation, immunochemical, and electrophoretic assays.
Evaluated MP removal using biophysical and functional assays, including thrombin generation assays.

Main Results:

Nanofiltration successfully removed over 9 logs of MPs.
Preserved protein and lipoprotein profiles, coagulation factor content, and global coagulation activity.
Markedly reduced plasma in vitro thrombogenicity, with no thrombin generation observed under low phospholipid conditions.

Conclusions:

75-nm nanofiltration efficiently removes MPs from plasma.
This process decreases in vitro thrombogenicity without compromising protein content or hemostatic activity.
Further studies are required to investigate the in vivo implications for thrombotic risk and hemostatic efficacy.