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Lack of protection against ebola virus from chloroquine in mice and hamsters
Emerging Infectious Diseases
|May 20, 2015
Abstract:
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
Keywords:
Ebola virus infectionanimal modelantimicrobial drugsantiviral drugchloroquinetreatmentviruses
